Product Introduction
Bioactivity


英文名: DDP-38003 trihydrochloride

描述: DDP-38003 trihydrochloride 是一种新型，可口服的KDM1A/LSD1抑制剂，IC50值为84 nM。

体外活性: DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony-forming ability and in inducing the differentiation of THP-1 cells than the 1R, 2S analogue [1].

体内活性: DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 has the potential as cancer therapeutic [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (217.47 mM)


关键字: DDP 38003 Trihydrochloride | DDP 38003 trihydrochloride | DDP-38003 Trihydrochloride | DDP38003 | DDP38003 Trihydrochloride | DDP 38003 | DDP38003 trihydrochloride | DDP-38003