Product Introduction
Bioactivity


英文名: IFN alpha-IFNAR-IN-1

描述: IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).

体外活性: IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR interaction inhibitor IFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: IFN α-IFNAR-IN-1 | IFN alphaIFNARIN1 | IFN a-IFNAR-IN-1 | IFN alpha-IFNAR-IN-1 | IFN alpha IFNAR IN 1