Product Introduction
Bioactivity


英文名: CB-103

描述: CB-103 是口服具有活性的蛋白相互作用抑制剂，靶向 NOTCH 转录复合体，具有抗肿瘤作用。

体外活性: CB-103在人类T细胞急性淋巴细胞性白血病（T-ALL）癌细胞系中显示出阻断NOTCH信号传递的能力，并且在对GSI抗性的T-ALL细胞系中表现出抗肿瘤效果[2]。

体内活性: CB-103在三阴性乳腺癌中抑制GSI/Mab耐药细胞的生长，并在人类T-ALL和小鼠乳腺肿瘤异种移植模型中展现出抗肿瘤活性[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (206.34 mM)


关键字: CB 103 | CB-103 | pathway | CB103 | inhibit | Inhibitor | Notch | signaling | leukemia

相关产品: Jagged-1 (188-204) TFA(219127-21-6 free base) | NGP555 | gamma-secretase modulator 1 | Nirogacestat | Fosciclopirox | PE859 | Semagacestat | YO-01027 | MDR-1339 | Tangeretin

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Prostate Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Hematonosis Compound Library | Protease Inhibitor Library