Product Introduction
Bioactivity


英文名: PTUPB

描述: PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。

体外活性: PTUPB在包括人类黑色素瘤细胞和转化的内皮细胞在内的多种癌症细胞系中对细胞增殖的抑制作用较弱。然而，在连续施用3天后，PTUPB强烈抑制HUVEC的增殖[1]。

体内活性: PTUPB通过抑制LLC肿瘤生长达70-83%，展现出无明显毒副作用（与对照组相比没有体重减轻现象）。经过一段时间治疗后，PTUPB的血浆峰值浓度较高[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (183.97 mM)


关键字: Cyclooxygenase | inhibit | Non-alcoholic | COX | obesity | Metastasis | liver | fatty | steatosis | HUVECs | HFD | hepatic | Inhibitor | PTUPB | LLC | disease

相关产品: COX-2-IN-30 | Taiwanhomoflavone A | Revaprazan hydrochloride | (-)-Ibuprofenamide | Regaloside B | Hirsutanonol | Salicylamide | Pueroside B | Longiferone B | COX-1/2-IN-5

相关库: Anti-Aging Compound Library | Anti-Cancer Compound Library | Angiogenesis related Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Metabolism Compound Library | Covalent Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library