化合物 T12823 T12823
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Product IntroductionBioactivity英文名: S516描述: S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin pol
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Product Introduction
Bioactivity
英文名: S516
描述: S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
体外活性: S516 has potent cytotoxicity(HL-60, HCT116 and HCT15 cells with IC50s of 4.8 nM, 42.8 nM and 24.9 nM, respectively). S516 (30 nM; 16 hours; HL60 cells) treatmemt causes significant arrest of cells at the G2/M phase, resulting in apoptosis with concomitant loss of G0/G1 phase.
体内活性: In human LX-1 lung cancer and CX-1 colon cancer mouse xenografts,S516 (5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) .
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 12.5 mg/mL (28.57 mM)
关键字: S516 | S-516 | S 516
相关产品: VCMMAE | Taltobulin | MMAF | BRD9876 | MT189 | T807 | Entasobulin | INH6 | CID-663143 | Jasplakinolide
Bioactivity
英文名: S516
描述: S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
体外活性: S516 has potent cytotoxicity(HL-60, HCT116 and HCT15 cells with IC50s of 4.8 nM, 42.8 nM and 24.9 nM, respectively). S516 (30 nM; 16 hours; HL60 cells) treatmemt causes significant arrest of cells at the G2/M phase, resulting in apoptosis with concomitant loss of G0/G1 phase.
体内活性: In human LX-1 lung cancer and CX-1 colon cancer mouse xenografts,S516 (5-10 mg/kg; intraperitoneal injection; mice) treatment has promising antitumor activity (inhibition ratio (IR)> 63%) .
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 12.5 mg/mL (28.57 mM)
关键字: S516 | S-516 | S 516
相关产品: VCMMAE | Taltobulin | MMAF | BRD9876 | MT189 | T807 | Entasobulin | INH6 | CID-663143 | Jasplakinolide
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