Product Introduction
Bioactivity


英文名: S55746 hydrochloride

描述: S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.

体外活性: S55746 selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner.S55746 (0-1 μM) potently and selectively induces cell death.

体内活性: S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active inhibitor of BCL-2 . In RS4, S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth;11 and Toledo models time- and dose-dependently.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: S-55746 Hydrochloride | BLC 201 | BLC201 | S55746 Hydrochloride | BLC-201 | S 55746 Hydrochloride | S55746 hydrochloride | S-55746 hydrochloride

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