Product Introduction
Bioactivity


英文名: S55746

描述: S55746 (BLC201) 是一种有效、可口服、选择性的BCL-2抑制剂，其Ki 值和Kd 值分别为 1.3 nM 和 3.9 nM。它具有抗肿瘤活性且毒性低。

体外活性: S55746通过特异性抑制BCL-2并依赖BAX/BAK途径诱导细胞凋亡。在0至1µM浓度范围内，S55746能够有效且选择性地引发细胞死亡[1]。

体内活性: S55746是一种高效且耐受性良好的口服BCL-2抑制剂。S55746（20-100 mg/kg，p.o.）可抑制RS4 [1]异种移植瘤的生长。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 44 mg/mL (61.9 mM)


关键字: inhibit | S-55746 | BCL-201 | Inhibitor | S 55746 | Bcl-2 Family | BCL 201 | S55746 | BLC-201 | BCL201 | BLC 201

相关产品: Protodeltonin | Dehydrocorydaline | Clitocine | VU0661013 | Quercetin 3,4'-dimethyl ether | Liriodenine | Ginsenoside F4 | UMI-77 | MIM1 | Kobophenol A

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Highly Selective Inhibitor Library | Apoptosis Compound Library | Cuproptosis Compound Library | NO PAINS Compound Library