别嘌呤醇核糖苷 T13539
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Product IntroductionBioactivity英文名: Allopurinol riboside描述: Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside
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Product Introduction
Bioactivity
英文名: Allopurinol riboside
描述: Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用，Ki 为 277 μM。
体外活性: Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized by the corresponding enzymes in humans[1]. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration-dependent manner[2].
体内活性: 血浆中Allopurinol riboside 的低浓度主要是由于吸收不完全和快速的肾脏清除作用所导致的。普罗布内西德能够减少Allopurinol riboside 的肾脏清除率，延长其在血浆中的半衰期，并使血浆中Allopurinol riboside 的浓度增加三倍[3]。Allopurinol riboside 在给药后1.6小时血浆中浓度达到峰值，消除半衰期为3小时，且在治疗范围内保持稳态浓度[4]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (354.17 mM)
关键字: inhibit | Drug Metabolite | Allopurinol riboside | Inhibitor | Parasite | Endogenous Metabolite
相关产品: Trimethylammonium chloride | 2'-O-Methyladenosine | Arcyriaflavin A | Palmitoleic acid | L-(+)-Arabinose | 2,3-Diaminopropionic acid | Methylcobalamin | 3’-O-Methyl guanosine | Pyridoxine hydrochloride | Angiotensinogen (1-14), human acetate
相关库: Nucleotide Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Anti-Parasitic Compound Library | Antiparasitic Natural Product Library | Bioactive Compound Library
Bioactivity
英文名: Allopurinol riboside
描述: Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用，Ki 为 277 μM。
体外活性: Allopurinol riboside is effective against parasites including leishmaniasis and American trypanosomiasis. Allopurinol riboside is selectively toxic because it is not metabolized by the corresponding enzymes in humans[1]. Humoral immunity is not suppressed by Allopurinol riboside. Lymphocyte blastogenesis induced by PHA and Con A is significantly suppressed by Allopurinol riboside in a concentration-dependent manner[2].
体内活性: 血浆中Allopurinol riboside 的低浓度主要是由于吸收不完全和快速的肾脏清除作用所导致的。普罗布内西德能够减少Allopurinol riboside 的肾脏清除率，延长其在血浆中的半衰期，并使血浆中Allopurinol riboside 的浓度增加三倍[3]。Allopurinol riboside 在给药后1.6小时血浆中浓度达到峰值，消除半衰期为3小时，且在治疗范围内保持稳态浓度[4]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 95 mg/mL (354.17 mM)
关键字: inhibit | Drug Metabolite | Allopurinol riboside | Inhibitor | Parasite | Endogenous Metabolite
相关产品: Trimethylammonium chloride | 2'-O-Methyladenosine | Arcyriaflavin A | Palmitoleic acid | L-(+)-Arabinose | 2,3-Diaminopropionic acid | Methylcobalamin | 3’-O-Methyl guanosine | Pyridoxine hydrochloride | Angiotensinogen (1-14), human acetate
相关库: Nucleotide Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Anti-Parasitic Compound Library | Antiparasitic Natural Product Library | Bioactive Compound Library
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