N-乙酰-5-羟色胺 T1354
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Product IntroductionBioactivity英文名: N-Acetyl-5-hydroxytryptamine描述: N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪
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Product Introduction
Bioactivity
英文名: N-Acetyl-5-hydroxytryptamine
描述: N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体，能够有效激活TrkB 受体。
体外活性: N-Acetyl-5-hydroxytryptamine 以昼夜节律方式激活TrkB受体。N-Acetyl-5-hydroxytryptamine迅速且昼夜节律地激活TrkB，并以TrkB依赖的方式呈现抗抑郁效应。N-Acetyl-5-hydroxytryptamine能快速激活TrkB，但不激活TrkA或TrkC，并且这一过程不依赖神经营养因子和MT3受体[1]。
体内活性: 为探究N-Acetyl-5-hydroxytryptamine是否能够在体内触发TrkB激活，本研究使用了TrkB F616A基因敲入小鼠。研究发现，TrkB F616A的激活可以被1NMPP1（一种来源于激酶抑制剂PP1的衍生物）特异性阻断，从而导致TrkB零表型。为评估N-Acetyl-5-hydroxytryptamine是否能模仿BDNF的作用，制备了来自TrkB F616A基因敲入小鼠的皮层神经元。结果与先前报告一致，BDNF和NAS介导的TrkB磷酸化被1NMPP1选择性降低，而K252a无影响；同时，5-羟色胺或褪黑素对此无效。这些发现表明，NAS强烈诱导了野生型TrkB和TrkB F616A酪氨酸的磷酸化及激活[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (229.1 mM)
Ethanol : 10 mg/mL
关键字: Endogenous Metabolite | Tropomyosin related kinase receptor | inhibit | Inhibitor | Trk Receptor | N Acetyl 5 hydroxytryptamine | N-Acetyl-5-hydroxytryptamine | NAcetyl5hydroxytryptamine
相关产品: Amitriptyline hydrochloride | Tyrphostin AG 879 | CE-245677 | 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one | TRK-IN-23 | Entrectinib | BMS-754807 | Larotrectinib sulfate | 7,8-Dihydroxyflavone | PF-03814735
相关库: Anti-Tumor Natural Product Library | Human Endogenous Metabolite Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Tyrosine Kinase Inhibitor Library | Natural Product Library for HTS | Target-Focused Phenotypic Screening Library | Drug Metabolite/Impurity Library | Natural Product Library | Bioactive Compound Library
Bioactivity
英文名: N-Acetyl-5-hydroxytryptamine
描述: N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) 是褪黑激素的直接前体，能够有效激活TrkB 受体。
体外活性: N-Acetyl-5-hydroxytryptamine 以昼夜节律方式激活TrkB受体。N-Acetyl-5-hydroxytryptamine迅速且昼夜节律地激活TrkB，并以TrkB依赖的方式呈现抗抑郁效应。N-Acetyl-5-hydroxytryptamine能快速激活TrkB，但不激活TrkA或TrkC，并且这一过程不依赖神经营养因子和MT3受体[1]。
体内活性: 为探究N-Acetyl-5-hydroxytryptamine是否能够在体内触发TrkB激活，本研究使用了TrkB F616A基因敲入小鼠。研究发现，TrkB F616A的激活可以被1NMPP1（一种来源于激酶抑制剂PP1的衍生物）特异性阻断，从而导致TrkB零表型。为评估N-Acetyl-5-hydroxytryptamine是否能模仿BDNF的作用，制备了来自TrkB F616A基因敲入小鼠的皮层神经元。结果与先前报告一致，BDNF和NAS介导的TrkB磷酸化被1NMPP1选择性降低，而K252a无影响；同时，5-羟色胺或褪黑素对此无效。这些发现表明，NAS强烈诱导了野生型TrkB和TrkB F616A酪氨酸的磷酸化及激活[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (229.1 mM)
Ethanol : 10 mg/mL
关键字: Endogenous Metabolite | Tropomyosin related kinase receptor | inhibit | Inhibitor | Trk Receptor | N Acetyl 5 hydroxytryptamine | N-Acetyl-5-hydroxytryptamine | NAcetyl5hydroxytryptamine
相关产品: Amitriptyline hydrochloride | Tyrphostin AG 879 | CE-245677 | 3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one | TRK-IN-23 | Entrectinib | BMS-754807 | Larotrectinib sulfate | 7,8-Dihydroxyflavone | PF-03814735
相关库: Anti-Tumor Natural Product Library | Human Endogenous Metabolite Library | Kinase Inhibitor Library | Traditional Chinese Medicine Monomer Library | Tyrosine Kinase Inhibitor Library | Natural Product Library for HTS | Target-Focused Phenotypic Screening Library | Drug Metabolite/Impurity Library | Natural Product Library | Bioactive Compound Library
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