Product IntroductionBioactivity英文名:
iRucaparib-AP6描述: iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
体外活性: iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 level in a dose dependent manner, exhibits a half-maximal degrading concentration (DC50) of 82?nM (Dmax?=?92%).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (56.37 mM)
关键字:
iRucaparib-AP6 |
iRucaparib AP6 |
iRucaparibAP6 |
iRucaparib-AP-6