Product Introduction
Bioactivity


英文名: Buloxibutid

描述: Buloxibutid (AT2 receptor agonist C21) 是一种新型且具有选择性小分子 angiotensin II AT2 receptor (血管紧张素 II AT2 受体)激动剂，对 AT2 受体和 AT1 受体的 Ki 值分别为 0.4 nM 和 10 μM。

体内活性: Buloxibutid, with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rats. Which induces the outgrowth of neurite cells, stimulates p42/p44mapk, and enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats. And it lowers the mean arterial blood pressure in anesthetized, spontaneously hypertensive rats.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 22.5 mg/mL (47.31 mM)


关键字: Buloxibutid

相关产品: Angiotensin II human acetate | Azilsartan Medoxomil | BIBS 39 | Vicenin 3 | Ripisartan | Ramipril | Pivalopril | Alacepril | Omapatrilat | Fosinopril sodium

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Bioactive Compound Library