化合物 T14564 T14564
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Product IntroductionBioactivity英文名: BI-4924描述: BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3
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Product Introduction
Bioactivity
英文名: BI-4924
描述: BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM). It has excellent Microsomal and hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis at 72 h ( IC50: 2200 nM).
体外活性: BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor and it shows high selectivity against the majority of other dehydrogenase targets[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BI-4924 | BI 4924 | BI4924
Bioactivity
英文名: BI-4924
描述: BI-4924 is an inhibitor of phosphoglycerate dehydrogenase (PHGDH) (IC50=3 nM). It has excellent Microsomal and hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis at 72 h ( IC50: 2200 nM).
体外活性: BI-4924 is a highly potent co-factor nicotinamide adenine dinucleotide (NADH/NAD+)-competitive PHGDH inhibitor and it shows high selectivity against the majority of other dehydrogenase targets[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BI-4924 | BI 4924 | BI4924
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