化合物BI-671800 T14565
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Product IntroductionBioactivity英文名: BI-671800描述: BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结
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Product Introduction
Bioactivity
英文名: BI-671800
描述: BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50值分别为 4.5 和 3.7 nM。
体外活性: BI-671800 (compound A) exhibits low nM potency as a potent small-molecule antagonist of human or mouse CRTH2 in transfected cells[1].
体内活性: BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1]. BI-671800 (compound A) also effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 130 mg/mL (259.22 mM)
关键字: BI 671800 | Inhibitor | AP 761 | Prostaglandin Receptor | inhibit | BI671800 | AP761 | BI-671800
相关产品: Tyrphostin A25 | Monomethyl fumarate | BMS-903452 | Ginsenoside Rb2 | Bimatoprost acid | AM-4668 | VER-155008 | PU-WS13 hydrobromide | IBC 293 | NOX-6-18
相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library
Bioactivity
英文名: BI-671800
描述: BI-671800 (AP-761) 是高特异性的前列腺素 D2 受体拮抗剂，对哮喘有研究潜力，对人和小鼠 CRTH2 转染细胞中 PGD2 结合 CRTH2 的 IC50值分别为 4.5 和 3.7 nM。
体外活性: BI-671800 (compound A) exhibits low nM potency as a potent small-molecule antagonist of human or mouse CRTH2 in transfected cells[1].
体内活性: BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1]. BI-671800 (compound A) also effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 130 mg/mL (259.22 mM)
关键字: BI 671800 | Inhibitor | AP 761 | Prostaglandin Receptor | inhibit | BI671800 | AP761 | BI-671800
相关产品: Tyrphostin A25 | Monomethyl fumarate | BMS-903452 | Ginsenoside Rb2 | Bimatoprost acid | AM-4668 | VER-155008 | PU-WS13 hydrobromide | IBC 293 | NOX-6-18
相关库: Drug Repurposing Compound Library | ReFRAME Related Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | NO PAINS Compound Library
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