化合物 T14568 T14568
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Product IntroductionBioactivity英文名: BI8622描述: BI8622 is an ubiquitin ligase HUWE1 inhibitor (IC50: 3.1 μM).体外活性: BI8622 i
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Product Introduction
Bioactivity
英文名: BI8622
描述: BI8622 is an ubiquitin ligase HUWE1 inhibitor (IC50: 3.1 μM).
体外活性: BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells[1]. BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells[1]. BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1]. BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM[1]. BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (293.08 mM)
关键字: BI-8622 | BI8622 | BI 8622
Bioactivity
英文名: BI8622
描述: BI8622 is an ubiquitin ligase HUWE1 inhibitor (IC50: 3.1 μM).
体外活性: BI8622 induces HUWE1 ectopically expresses to abolish ubiquitination of MCL1 with an IC50 value of 6.8 μM in HeLa cells[1]. BI8622 (0-50 μM; 16 hours) retards the degradation of MCL1 in response to UV irradiation by inhibiting HUWE1 in HeLa cells[1]. BI8622 (10 μM; 1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1]. BI8622 suppresses colony formation of Ls174T cells with estimated IC50 value of 8.4 μM[1]. BI8622 inhibits MYC-dependent transactivation in colorectal cancer cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (293.08 mM)
关键字: BI-8622 | BI8622 | BI 8622
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