Product Introduction
Bioactivity


英文名: Ceruletide Ammonium Salt

描述: Ceruletide Ammonium Salt 是一种十肽，起源于热带青蛙的皮肤，是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂，也是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide Ammonium Salt 具有镇静活性，可用于研究慢性精神分裂症。

体外活性: Ceruletide Ammonium Salt shares chemical and biological similarities with the gastrointestinal hormones cholecystokinin (CCK) and gastrin II in humans. Ceruletide Ammonium Salt stimulates gallbladder contraction, pancreatic exocrine secretion, gastric fluid secretion, and motility in the distal duodenum, jejunum, ileum, and colon, while delaying gastric emptying and inhibiting motility in the proximal duodenum[2]. In vitro, Ceruletide Ammonium Salt activates NF-kappaB/Rel at supraphysiological doses rather than at physiological levels. This activation may induce a self-protective genetic program before cell damage occurs, potentially preventing a higher degree of injury to pancreatic acinar cells after excessive stimulation by secretagogues[1].

体内活性: Ceruletide Ammonium Salt can be utilized for animal modeling, specifically in constructing animal models of pancreatitis.Ceruletide Ammonium Salt (0.4-0.5 μg/kg, intravenous injection; 3-4 μg/kg, subcutaneous injection) induces conscious and complete vomiting and defecation in dogs, with full recovery observed 15-30 minutes and 2-4 hours after intravenous administration or subcutaneous injection, respectively. Ceruletide Ammonium Salt (5-15 ng/kg, intravenous) demonstrates a significant spasmogenic effect on the pylorus in rats. Additionally, Ceruletide Ammonium Salt can reduce blood pressure in anesthetized dogs[2].Ceruletide Ammonium Salt-stimulated serum bile acids (SBA) evasion eliminates exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. The effectiveness of Ceruletide Ammonium Salt-stimulated SBA in dogs with portosystemic shunts (PSS) may be as good as PP SBA stimulation, and it may be more sensitive in detecting hepatic dysfunction in dogs with upper respiratory disease (URD)[3].

存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Ceruletide Ammonium Salt | 17650-98-5 | 17650-98-5 Free base

相关产品: Mini Gastrin I, human acetate | CCK-A receptor inhibitor 1 | XL413 | Loxiglumide | Gastrin I (human) acetate | XL413 hydrochloride | Gastrin/CCK antagonist 1 | WAY-620645 | Spiroglumide | GV-150013X

相关库: Membrane Protein-targeted Compound Library