化合物 T14936 T14936
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Product IntroductionBioactivity英文名: Ivaltinostat描述: CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis a
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Product Introduction
Bioactivity
英文名: Ivaltinostat
描述: CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
体外活性: CG200745 induces the accumulation of p53. It promotes p53-dependent transactivation, and it also enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins [1,2]. CG-200745 (0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells. CG-200745 (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment. CG-200745 (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in the G2/M phase (69%) [3].
体内活性: CG-200745 (p.o.; 30?mg/kg/day; for 7 days) weaken inflammatory cytokines, adhesion molecules, oxidative stress in UUO kidneys [4].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CG 200745 | Ivaltinostat | CG200745
相关产品: BG45 | HDAC ligand-1 | RTS-V5 | Tefinostat | BRD 9757 | Valproic Acid | CM-675 | SGC-UBD253 | SW-100 | BRD 4354
Bioactivity
英文名: Ivaltinostat
描述: CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
体外活性: CG200745 induces the accumulation of p53. It promotes p53-dependent transactivation, and it also enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins [1,2]. CG-200745 (0-10 μM; 48 hours) reduces the Calu6 cells proliferation to 40% of untreated cells. CG-200745 (0-10 μM; 1-24 hours) treatment with low concentration significantly increases the acetylation of histone H3 and H4 in Calu6 cells at various sites in a time-dependent manner up to 24 hours after treatment. CG-200745 (3 μM; 1-24 hours) significantly increases Calu6 cells proportion in the G2/M phase (69%) [3].
体内活性: CG-200745 (p.o.; 30?mg/kg/day; for 7 days) weaken inflammatory cytokines, adhesion molecules, oxidative stress in UUO kidneys [4].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: CG 200745 | Ivaltinostat | CG200745
相关产品: BG45 | HDAC ligand-1 | RTS-V5 | Tefinostat | BRD 9757 | Valproic Acid | CM-675 | SGC-UBD253 | SW-100 | BRD 4354
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