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Product IntroductionBioactivity英文名: Alarelin Acetate描述: Alarelin Acetate 是一种合成的GnRH 激动剂。细胞实验: The cells are trypsinized i
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Product Introduction
Bioactivity
英文名: Alarelin Acetate
描述: Alarelin Acetate 是一种合成的GnRH 激动剂。
细胞实验: The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1].
体外活性: The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1].
体内活性: Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1].
存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 58 mg/mL
关键字: GnRH Receptor | Inhibitor | Gonadotropin releasing hormone receptor | inhibit | GNRHR | Alarelin Acetate
相关产品: LGnRH-III, lamprey acetate(147859-97-0 free base) | Relugolix | Phoenixin-14 | Buserelin Acetate (57982-77-1 free base) | Elagolix sodium | Abarelix | (R)-Elagolix | Cetrorelix diacetate | Cetrorelix Acetate | Linzagolix
相关库: Anti-COVID-19 Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Peptide Compound Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library
Bioactivity
英文名: Alarelin Acetate
描述: Alarelin Acetate 是一种合成的GnRH 激动剂。
细胞实验: The cells are trypsinized in a solution of 2.5 g/L trypsin and seeded in a 96-well plate. After the cells are grown for 24 h to approximately 800 g/L subconfluent state, 0.1 mL medium containing 2.5% calf serum and various concentrations (0.001, 0.1, 10 μM) of alarelin is added to each well, respectively, and incubated for 24 h in a CO2 incubator. Each concentration is tested in at least 12 wells. Briefly, 15 μL of MTT solution is added to each well and incubated for 4 h. Then, the medium and MTT are removed and 150 μL of DMSO is added to each well and shaken for 10 min to dissolve the crystal. The OD is determined at 490 nm using an ELISA reader[1].
体外活性: The cell viability in the presence of alarelin was significantly lower compared to in the absence of alarelin. The maximum stimulatory effect on cell viability was achieved at a concentration of 10-5 M and it acted in a dose-dependent manner[1].
体内活性: Alarelin could inhibit the gastric acid secretion both by direct actions on parietal cells in rats and by inhibiting vagous function[2]. Alarelin could markedly increase the ratio of G1 phase and decrease ratio of S phase of GSMC of rats[1].
存储条件: store at low temperature,keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 58 mg/mL
关键字: GnRH Receptor | Inhibitor | Gonadotropin releasing hormone receptor | inhibit | GNRHR | Alarelin Acetate
相关产品: LGnRH-III, lamprey acetate(147859-97-0 free base) | Relugolix | Phoenixin-14 | Buserelin Acetate (57982-77-1 free base) | Elagolix sodium | Abarelix | (R)-Elagolix | Cetrorelix diacetate | Cetrorelix Acetate | Linzagolix
相关库: Anti-COVID-19 Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Peptide Compound Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library
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