CGP37157 T14941
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Product IntroductionBioactivity英文名: CGP37157描述: CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3
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Product Introduction
Bioactivity
英文名: CGP37157
描述: CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) 是一种 Na+/Ca2+ 交换抑制剂，抑制 Na+ 诱导的豚鼠心脏线粒体中 Ca2+ 的释放，IC50 为 0.8 μM。
体外活性: Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity[2]. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 65 mg/mL (200.48 mM)
关键字: CGP 37157 | Inhibitor | CGP37157 | CGP-37157 | inhibit | Na+/Ca2+ Exchanger
相关产品: SN 6 | Terfenadine | SM-6586 | SEA0400 | KB-R7943 mesylate | Benzamil | FR183998 free base | PPADS tetrasodium
相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Sodium Channel Blocker Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library
Bioactivity
英文名: CGP37157
描述: CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) 是一种 Na+/Ca2+ 交换抑制剂，抑制 Na+ 诱导的豚鼠心脏线粒体中 Ca2+ 的释放，IC50 为 0.8 μM。
体外活性: Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity[2]. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 65 mg/mL (200.48 mM)
关键字: CGP 37157 | Inhibitor | CGP37157 | CGP-37157 | inhibit | Na+/Ca2+ Exchanger
相关产品: SN 6 | Terfenadine | SM-6586 | SEA0400 | KB-R7943 mesylate | Benzamil | FR183998 free base | PPADS tetrasodium
相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Mitochondria-Targeted Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Sodium Channel Blocker Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library
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