化合物CGP60474 T14943
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Product IntroductionBioactivity英文名: CGP60474描述: CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、C
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Product Introduction
Bioactivity
英文名: CGP60474
描述: CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。
体外活性: The IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK5/p25, CDK7/CyclinH, CDK4/CyclinD and CDK9/cycT, respectively[4].
体内活性: 在LPS内毒素血症模型中，CGP60474（10mg/kg；i.p.）抑制了IL-6水平并提高了存活率[3]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (140.52 mM)
H2O : < 0.1 mg/mL (insoluble)
关键字: inhibit | endotoxemic | CGP-60474 | Cyclin dependent kinase | LPS | PKC | Inhibitor | Protein kinase C | CDK | CGP60474 | selective | survival | ATP-competitive | IL-6 level | CGP 60474
相关产品: Bucillamine | Jaceidin | AZD4547 | VEGFR-2-IN-33 | KI8751 | CGP77675 | (Z)-Semaxinib | PD173074 | Tyrosine kinase-IN-1 | Ripretinib
相关库: Angiogenesis related Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Epigenetics Compound Library | Tyrosine Kinase Inhibitor Library | TGF-beta/Smad Compound Library
Bioactivity
英文名: CGP60474
描述: CGP60474 是一种高效的抗内毒素药物，抑制细胞周期蛋白依赖激酶(CDK) ，抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。
体外活性: The IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/CyclinB, CDK2/CyclinE, CDK2/CyclinA, CDK5/p25, CDK7/CyclinH, CDK4/CyclinD and CDK9/cycT, respectively[4].
体内活性: 在LPS内毒素血症模型中，CGP60474（10mg/kg；i.p.）抑制了IL-6水平并提高了存活率[3]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (140.52 mM)
H2O : < 0.1 mg/mL (insoluble)
关键字: inhibit | endotoxemic | CGP-60474 | Cyclin dependent kinase | LPS | PKC | Inhibitor | Protein kinase C | CDK | CGP60474 | selective | survival | ATP-competitive | IL-6 level | CGP 60474
相关产品: Bucillamine | Jaceidin | AZD4547 | VEGFR-2-IN-33 | KI8751 | CGP77675 | (Z)-Semaxinib | PD173074 | Tyrosine kinase-IN-1 | Ripretinib
相关库: Angiogenesis related Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Epigenetics Compound Library | Tyrosine Kinase Inhibitor Library | TGF-beta/Smad Compound Library
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