化合物CGS 15943 T14944
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Product IntroductionBioactivity英文名: CGS 15943描述: CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分
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Product Introduction
Bioactivity
英文名: CGS 15943
描述: CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分别为 3.5、4.2、16 和 50 nM。
体外活性: CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ (IC50: 1.1 μM). CGS 15943 shows slight inhibition on p110δ (IC50: 8.47 μM). CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 12.22 mg/mL (42.77 mM)
关键字: Adenosine Receptor | Phosphoinositide 3-kinase | P1 receptor | CGS15943 | PI3K | inhibit | CGS-15943 | Inhibitor | CGS 15943
相关产品: PQR530 | Dehydroglyasperin C | TASP0415914 | Polyporenic acid C | PIK-75 hydrochloride | WYE-687 | SAR-260301 | Autophinib | Pilaralisib | Vacuolin-1
相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library
Bioactivity
英文名: CGS 15943
描述: CGS 15943 是一种可口服的非黄嘌呤腺苷受体拮抗剂。在转染的 CHO 细胞中，其对人 A1、A2A、A2B 和 A3 腺苷受体的 Ki 分别为 3.5、4.2、16 和 50 nM。
体外活性: CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ (IC50: 1.1 μM). CGS 15943 shows slight inhibition on p110δ (IC50: 8.47 μM). CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 12.22 mg/mL (42.77 mM)
关键字: Adenosine Receptor | Phosphoinositide 3-kinase | P1 receptor | CGS15943 | PI3K | inhibit | CGS-15943 | Inhibitor | CGS 15943
相关产品: PQR530 | Dehydroglyasperin C | TASP0415914 | Polyporenic acid C | PIK-75 hydrochloride | WYE-687 | SAR-260301 | Autophinib | Pilaralisib | Vacuolin-1
相关库: Anti-Neurodegenerative Disease Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library
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