Product Introduction
Bioactivity


英文名: Ch55

描述: Ch55 (3,5-Di-tert-butylchalcone)是HL60细胞分化的有效诱导剂(EC50 = 200 nM)，与RAR-α和RAR-β受体显示出高亲和力。Ch55可用于有关癌症的研究。

体外活性: In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (109.7 mM)


关键字: Ch55

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相关库: Anti-Cancer Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Nuclear Receptor Compound Library | Anti-Cancer Active Compound Library | Bioactive Compound Library