化合物BF738735 T16530
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Product IntroductionBioactivity英文名: BF738735描述: BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂，IC50为 5.7 nM。体外活性: BF738735 effectively
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Product Introduction
Bioactivity
英文名: BF738735
描述: BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂，IC50为 5.7 nM。
体外活性: BF738735 effectively inhibits all viruses tested, with EC50s ranging between 4 and 71 nM. The cytotoxicity of BF738735, determined in parallel with the EC50 and using the same culture conditions for 3 to 4 days, is low, with CC50 values ranging from 11 to 65 μM, resulting in high selectivity indices. BF738735 exhibits a broad spectrum of antiviral activity, as it inhibits all tested species of enteroviruses and rhinoviruses, with 50% effective concentrations ranging between 4 and 71 nM. BF738735 also impairs PI4KIIIα, but only at an ~300-fold-higher concentration (IC50 of 1.7 μM). The activity of BF738735 is analyzed on a set of 150 cellular kinases, including 13 lipid kinases at a concentration of 10 μM. For all kinases, the inhibition is less than 10%, indicating that BF738735 specifically inhibits PI4KIIIβ in vitro. Low concentrations of BF738735 decrease the amount of luciferase to GuaHCl-treated levels, suggesting that the BF738735 blocks viral RNA replication. The EC50 of BF738735 in this assay is 77 nM, which is comparable to the inhibition observed in the multicycle assay for coxsackievirus serotype B3 (CVB3)[1].
体内活性: BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation. A complete inhibition with 25 mg/kg and some inhibition with 5 mg/kg dose is observed[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (293.11 mM)
关键字: BF738735 | Phosphatidylinositol 4 kinases | Inhibitor | PI4 kinases | BF-738735 | inhibit | Reverse Transcriptase | PI4K | BF 738735
相关产品: LHF-535 | pocapavir | cis-Vaccenic acid | SARS-CoV-2-IN-39 | Capsorubin | 5-Hydroxy-7-acetoxy-8-methoxyflavone | ITMN4077 | A2ti-2 | Cyclosporin C | Xibornol
相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Metabolism Compound Library | Bioactive Compound Library
Bioactivity
英文名: BF738735
描述: BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂，IC50为 5.7 nM。
体外活性: BF738735 effectively inhibits all viruses tested, with EC50s ranging between 4 and 71 nM. The cytotoxicity of BF738735, determined in parallel with the EC50 and using the same culture conditions for 3 to 4 days, is low, with CC50 values ranging from 11 to 65 μM, resulting in high selectivity indices. BF738735 exhibits a broad spectrum of antiviral activity, as it inhibits all tested species of enteroviruses and rhinoviruses, with 50% effective concentrations ranging between 4 and 71 nM. BF738735 also impairs PI4KIIIα, but only at an ~300-fold-higher concentration (IC50 of 1.7 μM). The activity of BF738735 is analyzed on a set of 150 cellular kinases, including 13 lipid kinases at a concentration of 10 μM. For all kinases, the inhibition is less than 10%, indicating that BF738735 specifically inhibits PI4KIIIβ in vitro. Low concentrations of BF738735 decrease the amount of luciferase to GuaHCl-treated levels, suggesting that the BF738735 blocks viral RNA replication. The EC50 of BF738735 in this assay is 77 nM, which is comparable to the inhibition observed in the multicycle assay for coxsackievirus serotype B3 (CVB3)[1].
体内活性: BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation. A complete inhibition with 25 mg/kg and some inhibition with 5 mg/kg dose is observed[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 125 mg/mL (293.11 mM)
关键字: BF738735 | Phosphatidylinositol 4 kinases | Inhibitor | PI4 kinases | BF-738735 | inhibit | Reverse Transcriptase | PI4K | BF 738735
相关产品: LHF-535 | pocapavir | cis-Vaccenic acid | SARS-CoV-2-IN-39 | Capsorubin | 5-Hydroxy-7-acetoxy-8-methoxyflavone | ITMN4077 | A2ti-2 | Cyclosporin C | Xibornol
相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Colorectal Cancer Compound Library | Metabolism Compound Library | Bioactive Compound Library
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