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Product IntroductionBioactivity英文名: S-8921描述: S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.体外活性: S-8921 in
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Product Introduction
Bioactivity
英文名: S-8921
描述: S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.
体外活性: S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells (IC50 value of S-8921: 66±8 μM) [1].
体内活性: S-8921 treatment for 1 to 2 weeks induces a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective. S-8921(Seven-day) treatment induces a dramatic decrease in serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921 [1][2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: S 8921 | S-8921 | S8921
Bioactivity
英文名: S-8921
描述: S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.
体外活性: S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells (IC50 value of S-8921: 66±8 μM) [1].
体内活性: S-8921 treatment for 1 to 2 weeks induces a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective. S-8921(Seven-day) treatment induces a dramatic decrease in serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921 [1][2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: S 8921 | S-8921 | S8921
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