Product Introduction
Bioactivity


英文名: SMIP004

描述: SMIP004 是一种 SKP2 E3 连接酶抑制剂。 SMIP004 是人前列腺癌细胞的癌细胞特异性凋亡诱导剂。

体外活性: SMIP004通过降低正向细胞周期调节因子的水平并上调细胞周期依赖性激酶抑制剂, 从而导致G1期阻滞、抑制软琼脂中的集落形成以及细胞死亡[2]。

体内活性: 在SCID小鼠中，SMIP004有效抑制前列腺和乳腺癌异种移植瘤的生长[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (487.09 mM)


关键字: E1 activating enzyme | SMIP004 | Inhibitor | Apoptosis | Ubiquitin ligase | E2 conjugating enzyme | Ubiquitin activating enzyme | inhibit | E3 ligating enzyme | SMIP 004 | SMIP-004 | E1/E2/E3 Enzyme | Ubiquitin conjugating enzyme

相关产品: Tubulin inhibitor 11 | Crebanine | 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one | AGN 192870 | Terfenadine | FX1 | Diethyl phthalate | Hexylresorcinol | Diatrizoic Acid | Enpp/Carbonic anhydrase-IN-2

相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library