化合物UNC0224 T17203
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Product IntroductionBioactivity英文名: UNC0224描述: UNC0224 是 G9a 的特异性抑制剂，Ki 为 2.6 nM，IC50 为 15 nM。 UNC0224 还有效抑制 GLP，IC50 值为
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Product Introduction
Bioactivity
英文名: UNC0224
描述: UNC0224 是 G9a 的特异性抑制剂，Ki 为 2.6 nM，IC50 为 15 nM。 UNC0224 还有效抑制 GLP，IC50 值为 20-58 nM。
体外活性: In G9a ECSD and CLOT assays, the IC50 values are 43 nM and 57 nM for UNC0224, respectively. In GLP ECSD and CLOT assays, the IC50 values are 50 nM and 58 nM for UNC0224, respectively. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. In ITC experiments, the Kd of UNC0224 to the G9a protein is 23 nM[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 16 mg/mL (32.94 mM)
关键字: K373 | G9a | PKMT | lysine | UNC 0224 | SAR | stabilized | p53 | inhibit | quinazoline | UNC0224 | H3K9 | GLP | Inhibitor | Histone Methyltransferase | UNC-0224 | chromatin
相关产品: Menin-MLL inhibitor MI-2 | SMYD3-IN-1 | Dot1L-IN-2 | GSK3368715 3HCl | A-366 | Tanshindiol C | Ryuvidine | Tanshindiol B | MS049 2HCl (1502816-23-0(free base)) | SGC2085
相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library
Bioactivity
英文名: UNC0224
描述: UNC0224 是 G9a 的特异性抑制剂，Ki 为 2.6 nM，IC50 为 15 nM。 UNC0224 还有效抑制 GLP，IC50 值为 20-58 nM。
体外活性: In G9a ECSD and CLOT assays, the IC50 values are 43 nM and 57 nM for UNC0224, respectively. In GLP ECSD and CLOT assays, the IC50 values are 50 nM and 58 nM for UNC0224, respectively. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3, and JMJD2E. In ITC experiments, the Kd of UNC0224 to the G9a protein is 23 nM[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 16 mg/mL (32.94 mM)
关键字: K373 | G9a | PKMT | lysine | UNC 0224 | SAR | stabilized | p53 | inhibit | quinazoline | UNC0224 | H3K9 | GLP | Inhibitor | Histone Methyltransferase | UNC-0224 | chromatin
相关产品: Menin-MLL inhibitor MI-2 | SMYD3-IN-1 | Dot1L-IN-2 | GSK3368715 3HCl | A-366 | Tanshindiol C | Ryuvidine | Tanshindiol B | MS049 2HCl (1502816-23-0(free base)) | SGC2085
相关库: Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library
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