Product Introduction
Bioactivity


英文名: Zatosetron maleate

描述: Zatosetron maleate（LY 277359 maleate） 是一种具有有效性和选择性的血清素 5HT3 受体拮抗剂，可用于研究急性偏头痛。

体内活性: Acute administration of Zatosetron maleate (Zatosetron) at doses of 0.1 (n=21) and 0.3 (n=5) mg/kg in male rats, but not at doses of 0.01, 0.05, 1.0, or 10 mg/kg (n=5, 3, 6, and 4, respectively) Zatosetron maleate or saline (n=5), results in a significant reduction in the number of spontaneously active A10 dopamine cells. The number of spontaneously active A10 dopamine cells is not significantly different from 30 to 60 min post i.p. Zatosetron maleate (0.1 mg/kg) administration, shows a significant decrease by 60 to 90 min (0.65±0.11, P=0.03, n=5), a larger decrease by 90 to120 min (0.53±0.08, P=0.004, n=5), and remains at this significantly decreased level from 2 to 3 h (0.50+0.05, P=0.0004, n=5). Single-unit recordings demonstrate that Zatosetron maleate inhibits the activity of A10 dopamine cells following i.v. administration (ED50=0.12 mg/kg, n=8). Chronic administration of 0.1 mg/kg (n=16) Zatosetron maleate, but not 0.01, 1.0, or 10 mg/kg (n=4, 8, and 7, respectively) Zatosetron maleate or saline (n=5), leads to a significant reduction in the number of spontaneously active A10 dopamine cells[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Zatosetron Maleate | LY 277359 Maleate | LY277359 Maleate | LY-277359 Maleate

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相关库: Membrane Protein-targeted Compound Library