Product Introduction
Bioactivity


英文名: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride

描述: Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。它可用于 PROTAC 的合成分子。

体外活性: PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 100 mg/mL (219.85 mM)
DMSO : 125 mg/mL (274.81 mM)


关键字: Inhibitor | Thalidomide-O-amido-PEG-C2-NH2 Hydrochloride | Thalidomide-O-amido-PEG-C-2-NH2 hydrochloride | ThalidomideOamidoPEGC2NH2 hydrochloride | inhibit | Thalidomide O amido PEG C2 NH2 hydrochloride | E3 Ligase Ligand-Linker Conjugates

相关产品: Thalidomide-NH-C6-NH2 hydrochloride | Pomalidomide-C3-NH2 hydrochloride | Pomalidomide 4'-PEG2-azide  | Thalidomide-O-C4-NH2 hydrochloride | (S,R,S)-AHPC-PEG3-NH2 hydrochloride | Thalidomide-NH-PEG1-NH2 hydrochloride | Thalidomide-O-amido-C6-NH2 hydrochloride | Pomalidomide-PEG3-CO2H | (S,R,S)-AHPC-PEG3-N3 | Thalidomide-O-amido-PEG2-C2-NH2 TFA