Product Introduction
Bioactivity


英文名: Pentabromophenol

描述: Pentabromophenol (NSC-5717) 通过加速 TGF-β 受体的转换率来抑制 TGF-β 反应。

体外活性: Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 4.89 mg/mL (10 mM)


关键字: Pentabromophenol

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