化合物WS6 T2106
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Product IntroductionBioactivity英文名: WS6描述: WS6 是一种具有促beta 细胞增生作用的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。细胞实验: R7T1 cells are g
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Product Introduction
Bioactivity
英文名: WS6
描述: WS6 是一种具有促beta 细胞增生作用的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。
细胞实验: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)
激酶实验: PARP assays are conducted in a buffer containing 50 mM Tris (pH 8.0), 1 mM DTT, 1.5 μM [3H]NAD+?(1.6 μCi/mmol), 200 nM biotinylated histone H1, 200 nM slDNA, and 1 nM PARP-1 or 4 nM PARP-2 enzyme. Reactions are terminated with 1.5 mM benzamide, transferred to streptavidin Flash plates, and counted using a TopCount microplate scintillation counter.
体外活性: 在切除β细胞的RIP-DTA小鼠模型中,给口服WS6（50 mg/kg ）能够β细胞增殖,从而改善糖尿病.
体内活性: 在R7T1细胞中（EC50=0.28 μM）,WS6通过Erb3结合蛋白-1和IκB激酶信号通路作用,诱导细胞增殖。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 93 mg/mL (163.6 mM)
Ethanol : 93 mg/mL (163.6 mM)
关键字: inhibit | WS6 | Inhibitor | WS 6 | WS-6
相关产品: EGFR/BRAFV600E-IN-3 | Dacomitinib | Coprelotamab | EGFR-IN-9 | Tyrphostin AG 528 | EGFR-IN-85 | JGK-068S | Chamigrenal | Norcantharidin | Erlotinib hydrochloride
相关库: JAK-STAT Compound Library | Anti-Liver Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Anti-Diabetic Compound Library | Tyrosine Kinase Inhibitor Library
Bioactivity
英文名: WS6
描述: WS6 是一种具有促beta 细胞增生作用的新型小分子，在啮齿类动物和人源原发性胰岛中EC50值为0.28uM。
细胞实验: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)
激酶实验: PARP assays are conducted in a buffer containing 50 mM Tris (pH 8.0), 1 mM DTT, 1.5 μM [3H]NAD+?(1.6 μCi/mmol), 200 nM biotinylated histone H1, 200 nM slDNA, and 1 nM PARP-1 or 4 nM PARP-2 enzyme. Reactions are terminated with 1.5 mM benzamide, transferred to streptavidin Flash plates, and counted using a TopCount microplate scintillation counter.
体外活性: 在切除β细胞的RIP-DTA小鼠模型中,给口服WS6（50 mg/kg ）能够β细胞增殖,从而改善糖尿病.
体内活性: 在R7T1细胞中（EC50=0.28 μM）,WS6通过Erb3结合蛋白-1和IκB激酶信号通路作用,诱导细胞增殖。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 93 mg/mL (163.6 mM)
Ethanol : 93 mg/mL (163.6 mM)
关键字: inhibit | WS6 | Inhibitor | WS 6 | WS-6
相关产品: EGFR/BRAFV600E-IN-3 | Dacomitinib | Coprelotamab | EGFR-IN-9 | Tyrphostin AG 528 | EGFR-IN-85 | JGK-068S | Chamigrenal | Norcantharidin | Erlotinib hydrochloride
相关库: JAK-STAT Compound Library | Anti-Liver Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Anti-Diabetic Compound Library | Tyrosine Kinase Inhibitor Library
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