化合物BRD6688 T21715
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Product IntroductionBioactivity英文名: BRD6688描述: BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25
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Product Introduction
Bioactivity
英文名: BRD6688
描述: BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中，它可透过血脑屏障，并改善由p25 引起的神经退行性病变相关的记忆缺陷。
体内活性: Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : ≤2mg/ml
dimethyl formamide : 30mg/ml
DMSO : 50 mg/mL (177.09 mM)
关键字: Histone deacetylases | HDAC | inhibit | BRD6688 | BRD 6688 | BRD-6688 | Inhibitor
相关产品: ACY-775 | 9-hydroxy Stearic Acid | Mz325 | (2R/S)-6-PNG | HDAC6-IN-23 | Tubastatin A | ACY-957 | BEBT-908 | HNHA | Resminostat
相关库: Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library
Bioactivity
英文名: BRD6688
描述: BRD6688 为 HDAC2 的选择性抑制剂。本品可使原代小鼠神经元细胞中的 H4K12 和 H3K9 组蛋白的乙酰化作用增强。在 CK-p25 小鼠模型中，它可透过血脑屏障，并改善由p25 引起的神经退行性病变相关的记忆缺陷。
体内活性: Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : ≤2mg/ml
dimethyl formamide : 30mg/ml
DMSO : 50 mg/mL (177.09 mM)
关键字: Histone deacetylases | HDAC | inhibit | BRD6688 | BRD 6688 | BRD-6688 | Inhibitor
相关产品: ACY-775 | 9-hydroxy Stearic Acid | Mz325 | (2R/S)-6-PNG | HDAC6-IN-23 | Tubastatin A | ACY-957 | BEBT-908 | HNHA | Resminostat
相关库: Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Epigenetics Compound Library | Histone Modification Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library
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