化合物SQ 22536 T2172
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Product IntroductionBioactivity英文名: SQ22536描述: SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。细胞实验: HMC
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Product Introduction
Bioactivity
英文名: SQ22536
描述: SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。
细胞实验: HMC-1 cells and hCBMCs are plated in 48-well plates and serum-starved overnight. The next day, cells are preincubated with SQ22536 at the indicated concentrations for 30 min before stimulation with CRH (100 nM for HMC-1 or 1 μM for hCBMC) for 3 min in the presence or absence of SQ22536 in serum-free culture media. Cell lysates are then prepared and assayed for protein kinase A activity using ELISA.(Only for Reference)
体外活性: SQ22536(250 μMol/L) attenuates the inhibitory effect of adenosine against ADP-induced platelet aggregation from 8±5 to 57±5%, respectively (p<0.001). SQ22536 also attenuates an increase of intraplatelet levels of cAMP by adenosine from 29±2 to 9±1 pmol/108 platelets (p<0.05). It has no effect on the platelet antiaggregant activity of inosine (1 to 4 mmol/L) and ADP-induced platelet aggregation[4].
体内活性: SQ22536 abolishes the renal protective effects of liraglutide in KK/Ta-Akita mice. the amelioration of glomerular histopathological damage by liraglutide is eliminated in KK/Ta-Akita mice treated with liraglutide in combination with SQ22536. Renal cAMP does not increase after treatment with SQ22536. In a word, the beneficial actions of liraglutide for treatment of nephropathy are inhibited by the adenylate cyclase inhibitor SQ22536[5].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10.3 mg/mL (50 mM)
关键字: SQ-22536 | SQ22536 | Inhibitor | inhibit | Adenylate Cyclase | Adenylyl cyclase
相关产品: MC-Val-Cit-PAB | Thonzylamine hydrochloride | Piperidolate | VU0152099 | Anisotropine Methylbromide | Metixene hydrochloride hydrate | Minaprine | SCH-900271 | PNU-282987 | Paroxetine hydrochloride
相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Coagulation and Anticoagulation Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library
Bioactivity
英文名: SQ22536
描述: SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。
细胞实验: HMC-1 cells and hCBMCs are plated in 48-well plates and serum-starved overnight. The next day, cells are preincubated with SQ22536 at the indicated concentrations for 30 min before stimulation with CRH (100 nM for HMC-1 or 1 μM for hCBMC) for 3 min in the presence or absence of SQ22536 in serum-free culture media. Cell lysates are then prepared and assayed for protein kinase A activity using ELISA.(Only for Reference)
体外活性: SQ22536(250 μMol/L) attenuates the inhibitory effect of adenosine against ADP-induced platelet aggregation from 8±5 to 57±5%, respectively (p<0.001). SQ22536 also attenuates an increase of intraplatelet levels of cAMP by adenosine from 29±2 to 9±1 pmol/108 platelets (p<0.05). It has no effect on the platelet antiaggregant activity of inosine (1 to 4 mmol/L) and ADP-induced platelet aggregation[4].
体内活性: SQ22536 abolishes the renal protective effects of liraglutide in KK/Ta-Akita mice. the amelioration of glomerular histopathological damage by liraglutide is eliminated in KK/Ta-Akita mice treated with liraglutide in combination with SQ22536. Renal cAMP does not increase after treatment with SQ22536. In a word, the beneficial actions of liraglutide for treatment of nephropathy are inhibited by the adenylate cyclase inhibitor SQ22536[5].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 10.3 mg/mL (50 mM)
关键字: SQ-22536 | SQ22536 | Inhibitor | inhibit | Adenylate Cyclase | Adenylyl cyclase
相关产品: MC-Val-Cit-PAB | Thonzylamine hydrochloride | Piperidolate | VU0152099 | Anisotropine Methylbromide | Metixene hydrochloride hydrate | Minaprine | SCH-900271 | PNU-282987 | Paroxetine hydrochloride
相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Coagulation and Anticoagulation Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Infection Compound Library | Bioactive Compound Library
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