Product Introduction
Bioactivity


英文名: AMI-193

描述: AMI-193 (Spiramide) 是一种有效和选择性的 5-HT2 和 D2 受体，对 5-HT2、D2 受体、5-HT1A、D1 受体和 5-HT1C 受体的 Kis 分别为 2、3、50、2530 和 4300 nM。 AMI-193 显示出抗精神病活性。

体内活性: In adult male squirrel monkeys, AMI-193 (0.003 and 0.01 mg/kg; i.m.) decreases the response rate under a fixed-interval (FI) schedule of stimulus termination in a dose-dependent manner and under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). AMI-193 (0.003 and 0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 15 mg/mL (39.12 mM)


关键字: AMI-193 | AMI 193 | AMI193

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