Product IntroductionBioactivity英文名:
AR-R 17779 hydrochloride描述: AR-R17779 hydrochloride 是一种有效和选择性的 nAChR 完全激动剂,对α7和α4β2亚型的Ki 直分别为 92 和 16000 nM。AR-R17779 hydrochloride 可以改善大鼠的学习和记忆能力。AR-R17779 hydrochloride 也具有抗焦虑活性。AR-R17779 hydrochloride 可通过激活抗炎胆碱能(迷走神经)通路减轻炎症。
体外活性: AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine at the α7 nicotinic receptor [1]. AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages [4].
体内活性: AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) improves arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction [3]. AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats [2]. Animal Model: Male DBA/1 mice (8-10 weeks) were subjected to unilateral cervical vagotomy or sham surgery, after which arthritis was induced with type II collagen [3] Dosage: 1, 2.5, 5 mg/kg Administration: I.p. twice daily from day 20 until day 26 Result: Ameliorated arthritis and delayed onset of disease. Reduced erosive disease, cartilage degradation and synovial inflammation. Reduced TNFα levels in plasma and synovial tissue.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字:
ARR 17779 hydrochloride |
AR-R17779 Hydrochloride |
AR-R-17779 Hydrochloride |
AR-R 17779 Hydrochloride |
AR R 17779 hydrochloride