化合物Drinabant T21861
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Product IntroductionBioactivity英文名: Drinabant描述: Drinabant (AVE-1625) 是具有口服活性的 CB1 受体的拮抗剂。Drinabant 抑制 hCB1-R 和 rCB1-R 激动
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Product Introduction
Bioactivity
英文名: Drinabant
描述: Drinabant (AVE-1625) 是具有口服活性的 CB1 受体的拮抗剂。Drinabant 抑制 hCB1-R 和 rCB1-R 激动剂刺激的钙信号的 IC50 分别为 25 nM 和 10 nM。对 hCB2-R 无活性。
体内活性: Drinabant (10 mg/kg orally once daily), combined with Olanzapine attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2]. Drinabant (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (100.52 mM)
关键字: Drinabant | AVE 1625
相关产品: A-836339 | OMDM-6 | NESS 0327 | 6-Iodopravadoline | CB1 agonist 1 | CB2R/FAAH modulator-1 | BML-190 | O-1602 | GP 1a | GW 405833
相关库: GPCR Compound Library
Bioactivity
英文名: Drinabant
描述: Drinabant (AVE-1625) 是具有口服活性的 CB1 受体的拮抗剂。Drinabant 抑制 hCB1-R 和 rCB1-R 激动剂刺激的钙信号的 IC50 分别为 25 nM 和 10 nM。对 hCB2-R 无活性。
体内活性: Drinabant (10 mg/kg orally once daily), combined with Olanzapine attenuates body weight gain, diminishing the enhanced food intake while maintaining increased energy expenditure and decreased motility[2]. Drinabant (1, 3, and 10 mg/kg ip), reverses abnormally persistent LI induced by MK-801 or neonatal nitric oxide synthase inhibition in rodents, and improves both working and episodic memory[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (100.52 mM)
关键字: Drinabant | AVE 1625
相关产品: A-836339 | OMDM-6 | NESS 0327 | 6-Iodopravadoline | CB1 agonist 1 | CB2R/FAAH modulator-1 | BML-190 | O-1602 | GP 1a | GW 405833
相关库: GPCR Compound Library
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