化合物SC-1 T22424
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Product IntroductionBioactivity英文名: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea描述: SC-1 是一种 S
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Product Introduction
Bioactivity
英文名: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
描述: SC-1 是一种 Sorafenib 的衍生物，可抑制 STAT3磷酸化，通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡，具有抗癌作用。
细胞实验: Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 48 hours demonstrated that dose-dependent suppression of cell viability in all tested breast cancer cells[1]. Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 36 hours showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines and induced potent apoptotic activity[1].
动物实验: SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].
体外活性: SC-1(1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1]. SC-1(1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].
体内活性: SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (127.37 mM)
关键字: STAT | cyclin-D1 | Inhibitor | inhibit | kinase | Apoptosis | 1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea | p-STAT3 | orally | anticancer | SHP-1 | 1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea | survivin
相关产品: SKI V | Gomisin N | EPZ004777 hydrochloride | Alginic acid | saponaretin | Pantoprazole Sodium Hydrate | NHWD-870 | Ginsenoside Rk1 | 3-Dehydrotrametenolic acid | Isocurcumenol
相关库: Anti-Prostate Cancer Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library | NO PAINS Compound Library
Bioactivity
英文名: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
描述: SC-1 是一种 Sorafenib 的衍生物，可抑制 STAT3磷酸化，通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡，具有抗癌作用。
细胞实验: Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 48 hours demonstrated that dose-dependent suppression of cell viability in all tested breast cancer cells[1]. Incubated HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells with 1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM SC-1 for 36 hours showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines and induced potent apoptotic activity[1].
动物实验: SC-1 (10 mg/kg; oral gavage; daily; for 28 days; Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors[1].
体外活性: SC-1(1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells[1]. SC-1(1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity in association with downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines[1].
体内活性: SC-1 showes efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors in vivo[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (127.37 mM)
关键字: STAT | cyclin-D1 | Inhibitor | inhibit | kinase | Apoptosis | 1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea | p-STAT3 | orally | anticancer | SHP-1 | 1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea | survivin
相关产品: SKI V | Gomisin N | EPZ004777 hydrochloride | Alginic acid | saponaretin | Pantoprazole Sodium Hydrate | NHWD-870 | Ginsenoside Rk1 | 3-Dehydrotrametenolic acid | Isocurcumenol
相关库: Anti-Prostate Cancer Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Anti-Pancreatic Cancer Compound Library | Reprogramming Compound Library | NO PAINS Compound Library
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