Product Introduction
Bioactivity


英文名: McN-A 343

描述: McN-A 343作为选择性M1 muscarinic激动剂, 以其刺激交感神经节中muscarinic传导的能力而闻名。在溃疡性结肠炎的实验模型中，它已被发现能有效减轻炎症和氧化应激。

体内活性: 在6%乙酸引起的结肠炎模型中，使用McN-A 343以1.5 mg/kg的浓度进行治疗，显著降低了肠道损伤，并减少了湿重、MPO活性、促炎细胞因子浓度、氧化应激标志物以及炎症介质表达[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90 mg/mL (283.7 mM)
H2O : < 31.72 mg/mL


关键字: McN A 343 | McN-A 343 | McN-A343 | McN-A-343 | McNA 343

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