Product Introduction
Bioactivity


英文名: MDL 72527

描述: MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) 是一种多胺氧化酶 (POA) 抑制剂

体内活性: In the absence of CRP, exposure of platelets to MDL-72527 did not significantly modify [Ca2+]i, P-selectin abundance, αIIbβ3 integrin abundance, ROS, annexin-V-binding, and forward scatter. The addition of 2-5 μg/ml CRP was followed by significant increase of [Ca2+]i, P-selectin abundance, αIIbβ3 integrin activation, ROS abundance, annexin-V-binding, and aggregation as well as a significant decrease of forward scatter, all effects significantly blunted or virtually abolished in the presence of MDL-72527. MDL-72527 is a powerful inhibitor of platelet activation, apoptosis and aggregation[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 20 mg/ml (75.41 mM)


关键字: N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine | MDL72527 | MDL-72527 | MDL 72527

相关库: ReFRAME Related Library | Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library