Product Introduction
Bioactivity


英文名: ISX-1

描述: ISX-1 抑制脂肪生成并促进成骨细胞生成。 ISX-1 可用于骨质疏松症和骨质减少症的研究。

体外活性: In human bone marrow mesenchymal stem cells, ISX-1 (0-33 μM) inhibits the mRNA induction of PPARγ and FABP4 genes under the adipogenic differentiation of hBMSCs and promotes TCF/LEF-mediated gene transcription. ISX-1 inhibits the accumulation of intracellular lipid droplets(IC50 = 1.9 μM) and stimulated ALP activity(EC50 = 1.2 μM) in a dose-dependent manner[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.02 mg/mL (10 mM)


关键字: ISX1 | ISX-1

相关库: Bioactive Compounds Library Max | Bioactive Compound Library