Product Introduction
Bioactivity


英文名: Butyrolactone I

描述: Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。

体外活性: Butyrolactone I (70 and 100 μM) increases the percentage of DU145 cells in the 4C phase of the cell cycle. Butyrolactone I increases the amount of cyclin B1 positive cells in the 4C phase on day 1 and returns to normal by day 3. Butyrolactone I inhibits Cdc2 of unsynchronized cultured prostate cancer cells and interrupts the cell cycle progression toward cell division. The Butyrolactone I inhibition of Cdc2 led to the accumulation of cells in the 4C phase without mitosis resulting in an accumulation of cyclin B1[3].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Butyrolactone I

相关产品: Tacaciclib | Rigosertib | LY3177833 | CLK1-IN-3 | Olomoucine | AM5992 | Ribociclib succinate hydrate | THZ1-R | Indoramin D5 | AT7519

相关库: Rare Natural Product Library