盐酸伊伐布雷定 T2535
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Product IntroductionBioactivity英文名: Ivabradine hydrochloride描述: Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控
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Product Introduction
Bioactivity
英文名: Ivabradine hydrochloride
描述: Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
体内活性: Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine causes a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 93 mg/mL (184.1 mM)
Ethanol : 93 mg/mL (184.1 mM)
H2O : 75 mg/mL (148.5 mM)
关键字: heart rate | orally active | anticonvulsant | Inhibitor | Ivabradine | Ivabradine Hydrochloride | anti-ischaemic | anti-anginal | inhibit | Hyperpolarization activated cyclic nucleotide gated channels | Ivabradine hydrochloride | HCN Channel
相关产品: 2',5'-Dideoxyadenosine | Piperoxan hydrochloride | Scopine | SM-2470 | Nicergoline | Tolazoline hydrochloride | Aplindore Fumarate | Arformoterol Tartrate | Ketanserin tartrate | 2-(1-Piperazinyl)pyrimidine
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Endocrinology-Hormone Compound Library
Bioactivity
英文名: Ivabradine hydrochloride
描述: Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
体内活性: Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine causes a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 93 mg/mL (184.1 mM)
Ethanol : 93 mg/mL (184.1 mM)
H2O : 75 mg/mL (148.5 mM)
关键字: heart rate | orally active | anticonvulsant | Inhibitor | Ivabradine | Ivabradine Hydrochloride | anti-ischaemic | anti-anginal | inhibit | Hyperpolarization activated cyclic nucleotide gated channels | Ivabradine hydrochloride | HCN Channel
相关产品: 2',5'-Dideoxyadenosine | Piperoxan hydrochloride | Scopine | SM-2470 | Nicergoline | Tolazoline hydrochloride | Aplindore Fumarate | Arformoterol Tartrate | Ketanserin tartrate | 2-(1-Piperazinyl)pyrimidine
相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library | Endocrinology-Hormone Compound Library
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