Product Introduction
Bioactivity


英文名: EMD57033

描述: EMD57033是一种心脏肌钙蛋白C（cTnC）激活剂，是一种显性的Ca2+增敏剂。EMD57033通过与心脏/慢速骨骼肌钙蛋白C 异构体结合从而发挥促进心脏收缩的功能。

体外活性: EMD57033（5.0至5.8 mumol/L）能增强心肌收缩力并延长松弛时间。其效果受心率、[Ca2+]o 和收缩模式的调节，对于射血性心跳来说，正性肌力效应更为显著。[4]

体内活性: EMD-57033 (0.4 mg. kg(-1). min(-1) for 20 minutes) selective Ca(2+) sensitization with minimal PDE3I in vivo is achieved, improving basal and rate-stimulated contractility and mechanoenergetics of HF without compromising diastolic function. Despite PDE3I activity at higher doses, energetic benefits persist.[5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.0 mg/mL (105.8 mM)


关键字: EMD57033

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相关库: Anti-Cancer Metabolism Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library