Product Introduction
Bioactivity


英文名: Sophocarpine monohydrate

描述: Sophocarpine monohydrate 是从传统草药苦参中提取的一种重要生物碱，具有抗肿瘤活性，可用于肝细胞癌，前列腺癌和结肠直肠癌。苦参具有抗病毒，抗肿瘤和抗炎等多种药理作用。

体外活性: Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]

体内活性: 给BALB/c小鼠种植colon26腺癌异种移植物后，自恶病质起始时起，连续5天每天以50 mg/kg的剂量给予Sophocarpine，并未能抑制肿瘤生长，但能减轻恶病质症状。[1] LD50：小鼠63.94 mg/kg（静脉注射）[4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (243.56 mM)


关键字: Inhibitor | Protein kinase B | Sophocarpine Monohydrate | Phosphoinositide 3-kinase | Autophagy | Apoptosis | Influenza Virus | inhibit | Akt | Sophocarpine monohydrate | PKB | PI3K

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