Product Introduction
Bioactivity


英文名: Pyrazoloacridine

描述: Pyrazoloacridine (PD 115934) 是一种核酸结合剂，在 K562 细胞中抑制 topo I 和 II 的活性，IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。

体外活性: In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM[2]. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 15 mg/mL (40.83 mM)


关键字: tumor | Inhibitor | leukemia | inhibit | solid | Pyrazoloacridine | Apoptosis | PD115934 | carcinoma | pancreatic | myeloid | Topoisomerase | NSC366140

相关产品: HLCL-61 hydrochloride | Isoliquiritigenin | (R)-Isomucronulatol | Tomentosin | Alexidine dihydrochloride | Idebenone | TZ9 | MKC-1 | Palomid 529 | Bafilomycin A1

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Human Metabolite Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library