Product Introduction
Bioactivity


英文名: Soquinolol

描述: Soquinolol (Soquinolol mucate) 是一种β肾上腺素能受体拮抗剂，具有较弱的局部麻醉活性。Soquinolol 具有良好的肠内疗效和较长的作用持续时间。

体外活性: Soquinolol 在体外的豚鼠Langendorff心脏模型中，抑制了异丙肾上腺素引起的心动过速（EC50% = 48 μg/L）。[2]

体内活性: Soquinolol (5.5 μg/kg; intravenous injection; conscious dog) beta 1-adrenergic blocking activity (ED 50%) and oral administration (5.8 μg/kg; oral) is about twice as great as that of pindolol and 19 times (i.v.). These results suggest 95% enteral efficacy for soquinolol (pindolol 88%, propranolol 13%). The differences in soquinolol's and propranolol's efficacy detected in vitro and in vivo are partially attributable to differences in their kinetic properties namely the lower protein binding and the higher distribution volume of soquinolol. In the conscious dog, soquinolol inhibits beta 1-(ED 50% = 4.0 μg/kg) and beta 2 receptors (ED 50% = 2.7 μg/kg) at dose levels which do not differ significantly.[2]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (146.87 mM)


关键字: Soquinolol

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