Product Introduction
Bioactivity


英文名: UC-781

描述: UC-781 (NSC-675186) 是一种高效且具有选择性的人类免疫缺陷病毒 HIV-1 非核苷类逆转录酶(NNRTI)I抑制剂 ，C50 值为 5 nM。UC-781 具有抗病毒活性和耐药性。UC-781状态稳定，较低的 PH 或不同温度对其影响较小。

体外活性: UC-781 (0.05, 0.2, and 0.5 % UC-781 supplemented gel; 10 days) is released from the gel formulation and clears HIV-1 from CEM cells [1].UC-781 (3.75 -30 μM) inhibits the growth of Bacillus cereus (approximately 50%).[1] UC-781 inhibits HIV-1 (IIIB) activity in CEM T cells (EC50=6 nM; IC50=23 nM). UC-781 inhibits HIV activity in monocyte-derived dendritic cells (MO-DCs) and autologous CD4+ T cells with EC50 values of 550 nM and 1588 nM, respectively.[2] UC-781 (1000 nM; 24 h) effectively prevents or blocks HIV infection of monocyte-derived dendritic cells and autologous CD4+ T cells.[2] UC-781 (0.001-1000 µM; 2 h) inhibits viral transfer and infection of cervical explants with HIV-1BaL.[4]

体内活性: UC-781（每日一次，连续10天，经阴道给予100 µl 5% UC-781增强凝胶；雌性兔）从凝胶制剂中释放，对雌性兔正常组织显示出低毒性，且不显著增加炎症细胞。[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: NSC675186 | UC-781 | NSC-675186

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相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library