Product Introduction
Bioactivity


英文名: Sclareolide

描述: Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物，具有抗菌和细胞毒性作用。

激酶实验: Telomerase activity assay: The telomerase activity is measured by the TRAP assay using the TRAPez Telomerase Detection Kit, which includes primers of a 36-bp internal control (IC) for quantifying the amplification of telomerase activity within a linear range close to 2.5 logs. For RNase treatment, 10μL of extract are incubated with 1μg of RNase at 37 °C for 20 minutes. The products of the TRAP assay are resolved by electrophoresis in a nondenaturing12% PAGE in a buffer containing 0.5 × Tris–borate EDTA and detected by autoradiograph. For quantification of TRAP products, the dried gels are exposed to Fuji Imaging Plate at room temperature. Results are corrected for background, and a standard value of 100 is given to the untreated control cell signal. Signal intensities of Costunolide-treated cells are compared to the standard and are expressed as a fraction of the maximum value of 100. [1]

体内活性: Sclareolide被用于化妆品香料,尽管无临床证据支持,其最近还是被当作减肥品销售。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 47 mg/mL (187.7 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 47 mg/mL (187.7 mM)


关键字: Escherichia coli | Staphylococcus aureus | inhibit | Inhibitor | Bacterial | Sclareolide | Pseudomonas aeruginosa | Enterococcus faecalis

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