Product Introduction
Bioactivity


英文名: Bis-T-23

描述: Bis-T-23是一种肌动蛋白依赖性达纳敏低聚物的促进剂，是一种 HIV-I 整合酶抑制剂，是泰尔普斯丁衍生物。Bis-T-23可以促进肌动蛋白依赖性的dynamin 寡聚化。Bis-T-23可用于HIV 和慢性肾脏疾病（CKD）的研究。

体外活性: Bis-T-23 (AG1717) (0.18 μM) inhibits HIV-1 integrase.[5] AG1717 (2 μM) inhibits the binding of integrase to substrate DNA.[5]

体内活性: Bis-T-23 (1 ng) targets actin-dependent kinesin oligomerization in podocytes to promote normal GFB function.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) improves proteinuria by altering actin kinetics.[6] Bis-T-23 (i.p. ; 20, 40 mg/kg) ameliorates or prevents proteinuria and reduces thylakoid matrix expansion in various genetic and chronic glomerular disease models in rodents.[6]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : Insoluble
DMSO : 12.01 mg/ml (25 mM)


关键字: Bis-T-23 | AG-1717 | AG 1717

相关产品: Gomisin M2 | Emtricitabine S-oxide | 6-Acetonyldihydrochelerythrine | HIV-1 inhibitor-53 | Ivermectin | PTACH | Theaflavin 3,3'-digallate | Daurichromenic acid | Salmeterol Xinafoate | InteriotherinA

相关库: Bioactive Compounds Library Max | Inhibitor Library | Anti-Viral Compound Library | Bioactive Compound Library