Product Introduction
Bioactivity


英文名: BiP inducer X

描述: BiP inducer X (BIX) 是免疫球蛋白重链结合蛋白 (BiP)/GRP78 的选择性诱导剂和 ER 伴侣诱导剂。 BiP inducer X 可防止神经元和视网膜细胞系中的细胞死亡。

体外活性: Pretreatment of BiP inducer X (5 μM; 12 hours) inhibits cell death induced by ER stress involving inhibited activation of caspases 3/7 and 4. In SK-N-SH cells, BiP inducer X (5 μM; 0-12 hours) increases BiP protein and is mediated by activation of ER stress response elements (ERSEs) through the ATF6 pathway[1].

体内活性: 在成年雄性ddY小鼠中，BiP inducer X（20μg）减少了由中大脑动脉（MCA）闭塞引起的脑半暗带中ER压力诱导的凋亡。BiP inducer X 降低了由于脑梗塞[1]造成的损伤。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (215.08 mM)


关键字: GRP78 | Apoptosis | BiP inducer X | BiP | Inhibitor | inhibit | GRP94 | stress | neurons | calreticulin

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相关库: Bioactive Compounds Library Max | Bioactive Compound Library