化合物SMER28 T3155
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Product IntroductionBioactivity英文名: SMER28描述: SMER28 是一种自噬小分子增强剂，通过不依赖于 mTOR 的机制诱导哺乳动物细胞中独立于雷帕霉素的自噬，并阻止淀粉样蛋白 β 肽的积累。细胞实验:
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Product Introduction
Bioactivity
英文名: SMER28
描述: SMER28 是一种自噬小分子增强剂，通过不依赖于 mTOR 的机制诱导哺乳动物细胞中独立于雷帕霉素的自噬，并阻止淀粉样蛋白 β 肽的积累。
细胞实验: MEF cells overexpressing βCTF are treated with autophagy-enhancing compounds (10 μM) for 16 h. Cell lysates are analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies.(Only for Reference)
体外活性: SMER28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. A marked decrease in Aβ/APP-CTF levels and enhancement for degradation of Aβ/APP-CTF via autophagy is also induced by SMER28. APP-CTF and LC3-II are cocompartmentalized on SMER28 treatment[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 26.4 mg/mL (100 mM)
关键字: SMER28 | inhibit | Inhibitor | Autophagy | SMER-28 | SMER 28
相关产品: Wogonoside | Pogostone | WYE-354 | Ganoderic acid A | Pantoprazole Sodium Hydrate | Pirarubicin | Nordihydroguaiaretic acid | SKF-96365 hydrochloride | Obatoclax Mesylate | XRK3F2
相关库: Anti-Aging Compound Library | HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Autophagy Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library
Bioactivity
英文名: SMER28
描述: SMER28 是一种自噬小分子增强剂，通过不依赖于 mTOR 的机制诱导哺乳动物细胞中独立于雷帕霉素的自噬，并阻止淀粉样蛋白 β 肽的积累。
细胞实验: MEF cells overexpressing βCTF are treated with autophagy-enhancing compounds (10 μM) for 16 h. Cell lysates are analyzed by SDS-PAGE and Western blotting using anti-βCTF (6E10) and anti-tubulin antibodies.(Only for Reference)
体外活性: SMER28 is a positive regulator of autophagy in a mechanism independent from the mTOR pathway. It increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. A marked decrease in Aβ/APP-CTF levels and enhancement for degradation of Aβ/APP-CTF via autophagy is also induced by SMER28. APP-CTF and LC3-II are cocompartmentalized on SMER28 treatment[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 26.4 mg/mL (100 mM)
关键字: SMER28 | inhibit | Inhibitor | Autophagy | SMER-28 | SMER 28
相关产品: Wogonoside | Pogostone | WYE-354 | Ganoderic acid A | Pantoprazole Sodium Hydrate | Pirarubicin | Nordihydroguaiaretic acid | SKF-96365 hydrochloride | Obatoclax Mesylate | XRK3F2
相关库: Anti-Aging Compound Library | HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Autophagy Compound Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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