Product Introduction
Bioactivity


英文名: HSP70-IN-1

描述: HSP70-IN-1是一种热休克蛋白 (HSP) 抑制剂，可抑制 Kasumi-1 细胞的生长，IC50值为2.3 μM。

体外活性: The heat shock protein 70 (Hsp70) is a molecular chaperone that plays an important function in protein homeostasis and in cell signaling as well as survival. Hsp70 is frequently overexpressed in cancer, where the elevated expression is further thought to be a cause of or to lead to resistance to chemotherapy and other treatments. HSP70-IN-1 interferes with the formation of functional Hsp70-HOP-Hsp90 machinery by its ability to dose-dependently alter the megacomplex components and to destabilize an Hsp70-Hsp90 machinery client, Raf-1. In cells, the refolding of heat-denatured luciferase by endogenous as well as transfected Hsp70 is inhibited by HSP70-IN-1. HSP70-IN-1 also results in induction of apoptosis in cancer cells. Addition of HSP70-IN-1to cancer cells dose-dependently alters the formation of the Hsp70-HOP complex, a phenomenon associated with their destabilization and reduction in half-life[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (96.86 mM)


关键字: HSP70-IN-1 | HSP70 IN 1 | inhibit | HSP-70-IN-1 | Heat shock proteins | Inhibitor | HSP70IN1 | HSP

相关产品: HSP90-IN-27 | Paeoniflorin | KNK437 | VER-155008 | Eupalinolide A | MKT-077 | H2-Gamendazole | Alvespimycin | TRAP1-IN-2 | Feretoside

相关库: Anti-Aging Compound Library | Anti-Breast Cancer Compound Library | ReFRAME Related Library | Anti-Cancer Compound Library | Anti-Metabolism Disease Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Metabolism Compound Library | Bioactive Compound Library